SMART DESIGN
Bio BENC H is Modulari ty an d Flexibility at the same time.
As a matter of fact, the homogeneity of our control unit and software beside the vessel’s concept, offer full possibilities to work with several types of cells lines and micro-organisms without the need to modify instrument design

The modularity and flexibility of our control unit offer you the unique advantage of being able to start with 1 bioreactor that can then be upgraded to 2-4-6-12-24 and up to 36 bioreactors working online with the same or different vessel size and typology.

BioController module with industry leading PLC hardware, ModBus and Ethernet communication protocols to simplify and accelerate single and parallel bioreactor operations

Enhanched sensors capability integrating Online Biomass and Gas Analyzers, Automated samplers, HPLC, Mass Spec and othersGas mixing module supports 4-8 or more integrated massflow controllers per vessel, automated gas control strategy for cell culture or fermentation applications
Peristaltic pump module with 4-8 or more fix and variable programmable pumps per vessel with bi-direction flow for high precision dosing
Thermo module with built-in Chiller in a water saving closed loop. Accurate temperature control for single wall and water jacketed bioreactors

Single Jacket Vessels

Vessels feature an autoclavable borosilicate glass body and stainless steel head plate. Stainless-steel dished or round bottom vessels are available with a strong heating blanket for rapid heat transfer ideal for microbial and yeasts fermentations. Interchangeable magnetic and direct overhead drive options, a variety of impellers and multiple industry standard head plate ports are available for user flexibility. Rushton, pitched-blade, marine blade, spinfilter, cell-lift and packed-bed impellers available

Applications:

Research and Development in cell culture and microbiology Laboratory and pilot scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
Cultivation of mammalian, insect, and human cell lines
Specialized applications such as stem cell culture or biofuel/biopolymer development
Specialized packed-bed impeller for vaccine production in anchorage and non-anchorage dependent cell lines Suitable for batch, fed-batch, and continuous processes
Validation packages available for GMP-regulated processes

Features
Microbial and Cell culture configuration
Single and Jacketed glass vessel
Accurate temperature control independent for each vessel
PLC automation with HMI-PC interface touch screen
Fully controlled parameters include pH, pO2, temperature, foam/level, speed and more
Batch, Fed-Batch, Perfusion and Continuous cultivation
Stainless steel head plate and auxiliaries ports for sensors, septum, sparger aeration (L -sparger or porous sparger), multiple liquid inlets, sample pipe, Exhaust condenser
Mechanical or Magnetical stirrers up to 2000 rpm speed with height adjustable impellers (Rushton or Marine impellers)

Double Wall Vessels

Perfect design for multi purpose applications

Dished or round bottom vessels with stainless steel head plate designed according to the latest GMP requirements with a robust glass borosilicate vessel fully certified.
Our double wall vessels are available with a precise electrical heating module for accurate and gentle heat transfer and temperature control for cell culture and microbial fermentations. Interchangeable magnetic and direct overhead drive options, a variety of impellers and multiple industry standard head plate ports are available for user flexibility. Rushton, pitched-blade, marine blade, spinfilter, cell-lift and packed-bed impellers available.

Applications:

• Research and Development in cell culture and microbiology
• Laboratory and pilot scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
• Cultivation of mammalian, insect, and human cell lines
• Specialized applications such as stem cell culture or biofuel/biopolymer development
• Specialized packed-bed impeller for vaccine production in anchorage and non-anchorage dependent cell lines
• Suitable for batch, fed-batch, and continuous processes
• Validation packages available for GMP-regulated processes

Vessel volume

Sub Disposable Vessels
Solida Biotech SUB disposable bioreactors solutions help you to save downtime and eliminate the need to clean, autoclave and assemble your classic glass bioreactors.

You can benefit of our BIO BENCH COMPACT and ADVANCED Controllers platform to interchange and/or work in parallel your traditional STR glass bioreactors with the SUB disposable systems to boost your experiments. Our range of single-use, stirred tank bioreactor platform are available with sigle jacket and double wall vessels and enable you to get you to results faster.

All of our SUB disposable vessels can be used for cell cultures (animal-, insects-, and plant cells) but also for microbial and yeasts fermentation.
The control system can be configured for multi purpose applications with rotameters and Mass flow controllers for Air, O2, CO2 and N2, a precise Pumping module with fix and variable speed pumps. It can measure and control pH, temperature, dissolved oxygen (DO), Level/Foam and additional sensors and accessories.
Reusable sensors can be also provided for pH, temperature and dissolved oxygen.

The SUB bioreactor vessels are equipped with multiple addition-, sample- and harvesting tubing. All tubings are clear c-flex, suitable for tube welding. Multiple diameter sizes tubing are used provided for smaller and larger additions. Each line is also provided with luer lock connector. The sample ports are provided with luer lock connector. Four gas lines are present: gas inlet overlay, open pipe sparger, porous sparger and exhaust gas. All lines are provided with sterile (vent) filter.

Vessel volume